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GENE - TERM ANNOTATION REPORT

RGD ID: 69329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapt
Name: microtubule-associated protein tau
Acc ID: DOID:680
Term: tauopathy
Definition: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
Definition Source(s): MESH:D024801, http://en.wikipedia.org/wiki/Tauopathy
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
treatmentIDA 13800905RGD  
 ISORGD:73649611554173CTDCTD Direct Evidence: marker/mechanism

PMID:10604746, PMID:11889249, PMID:14595660, PMID:24556215, PMID:27569447
 ISORGD:73649613800888RGD  
treatmentISORGD:7364968158094RGD  
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.