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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapt
Name: microtubule-associated protein tau
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maptincreases phosphorylationEXP 6480464CTDStreptozocin results in increased phosphorylation of MAPT proteinPMID:31833155
Maptmultiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; N-acetyl-N-formyl-5-methoxykynurenamine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]PMID:31833155
Maptincreases expressionISOMapt (Mus musculus)6480464CTDStreptozocin results in increased expression of MAPT protein modified formPMID:34428446
Maptincreases phosphorylationISOMapt (Mus musculus)6480464CTDStreptozocin results in increased phosphorylation of MAPT proteinPMID:20976160 PMID:28422052
Maptmultiple interactionsISOMapt (Mus musculus)6480464CTD5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form]; Folic Acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; SOD2 protein inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form]PMID:20976160 PMID:28422052 PMID:34428446
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