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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapt
Name: microtubule-associated protein tau
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDParaquat results in decreased expression of MAPT protein

PMID:24521700
multiple interactionsISORGD:7364976480464CTD[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA, Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA], Paraquat results in increased phosphorylation of and results in increased expression of MAPT protein, Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]

PMID:22292029, PMID:23963992
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.