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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionEXP 6480464CTDHydroxyurea results in increased expression of CDKN1A proteinPMID:15557822
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDHydroxyurea results in increased expression of CDKN1A mRNAPMID:27208086 PMID:29228353
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDHydroxyurea results in increased expression of CDKN1A mRNA; Hydroxyurea results in increased expression of CDKN1A proteinPMID:10961388 PMID:10978678 PMID:16005713 PMID:18647660 PMID:21840268 PMID:24211769
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTDTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]PMID:29228353
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1A mRNA; Hydroxyurea inhibits the reaction [trichostatin A results in increased expression of CDKN1A protein]; Hydroxyurea inhibits the reaction [Valproic Acid results in increased expression of CDKN1A protein]PMID:17653085
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