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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]PMID:30555576
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]PMID:17977830 PMID:18223691 PMID:18347191 PMID:19735649 PMID:21840268 PMID:22927544 PMID:23274516 PMID:30555576
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