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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs2
Name: insulin receptor substrate 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irs2affects expressionEXP 6480464CTDEstradiol affects the expression of IRS2 mRNAPMID:32145629
Irs2decreases expressionISOIRS2 (Homo sapiens)6480464CTDEstradiol results in decreased expression of IRS2 mRNAPMID:19167446
Irs2increases expressionISOIRS2 (Homo sapiens)6480464CTDEstradiol results in increased expression of IRS2 mRNA; Estradiol results in increased expression of IRS2 proteinPMID:15949379
Irs2increases phosphorylationISOIRS2 (Homo sapiens)6480464CTDEstradiol results in increased phosphorylation of IRS2 proteinPMID:15949379
Irs2multiple interactionsISOIRS2 (Homo sapiens)6480464CTD[Estradiol co-treated with Norethindrone Acetate] results in increased expression of IRS2 mRNA; [Progesterone co-treated with Estradiol] results in increased expression of IRS2 mRNA; Estradiol promotes the reaction [Progesterone results in increased expression of IRS2 mRNA]; Estradiol promotes the reaction [Progesterone results in increased expression of IRS2 protein]; Estradiol promotes the reaction [Progesterone results in increased phosphorylation of IRS2 protein]PMID:15949379 PMID:17404688 PMID:22217510
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