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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad7
Name: SMAD family member 7
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad7increases expressionISOSMAD7 (Homo sapiens)6480464CTDTretinoin results in increased expression of SMAD7; Tretinoin results in increased expression of SMAD7 mRNAPMID:21934132 PMID:24374174 PMID:33167477
Smad7increases expressionISOSmad7 (Mus musculus)6480464CTDTretinoin results in increased expression of SMAD7 proteinPMID:16410076 PMID:33493612
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