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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:42944
Term: galanthamine
Definition: A benzazepine alkaloid isolated from certain species of daffodils.
Chemical ID: MESH:D005702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases activityEXP 6480464CTDGalantamine results in decreased activity of ACHE proteinPMID:18571635 PMID:19345205 PMID:29886234
Achemultiple interactionsEXP 6480464CTDGalantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]PMID:28837785
Achedecreases activityISOACHE (Homo sapiens)6480464CTDGalantamine results in decreased activity of ACHE proteinPMID:14535624 PMID:18573242 PMID:25522658 PMID:30905860 PMID:31125207
Achemultiple interactionsISOACHE (Homo sapiens)6480464CTDGalantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]PMID:25522658 PMID:27238725
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