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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69300
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1b2
Name: solute carrier organic anion transporter family member 1B2
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1b2increases importISOSLCO1B3 (Homo sapiens)6480464CTDSLCO1B3 results in increased import of 2,2',4,4'-tetrabromodiphenyl etherPMID:20176623
Slco1b2increases uptakeISOSlco1b2 (Mus musculus)6480464CTDSLCO1B2 protein results in increased uptake of 2,2',4,4'-tetrabromodiphenyl etherPMID:21884716
Slco1b2multiple interactionsISOSLCO1B3 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]PMID:20176623
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