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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:31206
Term: ammonium chloride
Definition: An inorganic chloride having ammonium as the counterion.
Chemical ID: MESH:D000643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1affects expressionEXP 6480464CTDAmmonium Chloride affects the expression of SQSTM1 mRNAPMID:16483693
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDAmmonium Chloride results in decreased expression of SQSTM1 proteinPMID:29908302
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDAmmonium Chloride results in increased expression of SQSTM1 proteinPMID:21778691 PMID:34405320
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD[Ammonium Chloride co-treated with pentabrominated diphenyl ether 100] results in increased expression of SQSTM1 protein; [Resveratrol co-treated with Ammonium Chloride] results in increased expression of SQSTM1 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Ammonium Chloride inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]; NR1I2 protein affects the reaction [Ammonium Chloride results in decreased expression of SQSTM1 protein]PMID:21778691 PMID:24262987 PMID:27234317 PMID:29908302
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