GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | multiple interactions | EXP | | 6480464 | CTD | Chloroquine promotes the reaction [Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]]; RAB7A protein promotes the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; Resveratrol affects the reaction [Benzo(a)pyrene affects the expression of SQSTM1 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]; Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]; Resveratrol promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]] | PMID:24889822 PMID:28713934 PMID:29222055 PMID:32619457 | Sqstm1 | decreases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | resveratrol results in decreased expression of SQSTM1 protein | PMID:24451142 | Sqstm1 | increases degradation | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | resveratrol results in increased degradation of SQSTM1 protein | PMID:24145604 PMID:25943029 | Sqstm1 | increases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | resveratrol results in increased expression of SQSTM1 protein | PMID:21778691 | Sqstm1 | increases expression | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | resveratrol results in increased expression of SQSTM1 protein | PMID:25505154 | Sqstm1 | multiple interactions | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | 3-methyladenine inhibits the reaction [resveratrol results in increased degradation of SQSTM1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased degradation of SQSTM1 protein]; [resveratrol co-treated with Ammonium Chloride] results in increased expression of SQSTM1 protein; [resveratrol co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [TNF protein co-treated with resveratrol] results in increased degradation of SQSTM1 protein; Adenylyl Cyclase Inhibitors inhibits the reaction [resveratrol results in increased degradation of SQSTM1 protein]; bafilomycin A inhibits the reaction [resveratrol inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [resveratrol results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [resveratrol results in increased degradation of SQSTM1 protein]; PRKACA protein promotes the reaction [resveratrol results in increased degradation of SQSTM1 protein]; resveratrol inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein]; resveratrol inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; SIRT1 protein promotes the reaction [resveratrol results in increased degradation of SQSTM1 protein] | PMID:21778691 PMID:24145604 PMID:24304514 PMID:24451142 PMID:25943029 | Sqstm1 | multiple interactions | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein]]; resveratrol inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; resveratrol inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein] | PMID:24304514 PMID:24889822 | | ||||||||||||||||||||||
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