GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | decreases expression | EXP | | 6480464 | CTD | Hydrogen Peroxide results in decreased expression of SQSTM1 protein | PMID:36639873 | Sqstm1 | increases expression | EXP | | 6480464 | CTD | Hydrogen Peroxide results in increased expression of SQSTM1 protein | PMID:24889822 | Sqstm1 | multiple interactions | EXP | | 6480464 | CTD | bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]; olaparib inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein]; RAB7A protein inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]; RAB7A protein promotes the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein] | PMID:24889822 PMID:36639873 | Sqstm1 | affects expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide affects the expression of SQSTM1 mRNA | PMID:23410634 | Sqstm1 | decreases expression | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | Hydrogen Peroxide results in decreased expression of SQSTM1 protein | PMID:34740634 | Sqstm1 | decreases response to substance | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | SQSTM1 protein results in decreased susceptibility to Hydrogen Peroxide | PMID:17360324 | Sqstm1 | increases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of SQSTM1 mRNA; Hydrogen Peroxide results in increased expression of SQSTM1 protein | PMID:28285367 PMID:34581912 | Sqstm1 | multiple interactions | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | [Hydrogen Peroxide co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in increased phosphorylation of SQSTM1 protein; DUSP5 protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein]; epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein] | PMID:31494107 PMID:34740634 | | ||||||||||||||||||||||
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