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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69250
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt5a
Name: Wnt family member 5A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt5aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of WNT5A mRNAPMID:34747641
Wnt5aaffects expressionISOWnt5a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of WNT5A mRNAPMID:24680724
Wnt5adecreases expressionISOWNT5A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of WNT5A mRNAPMID:20106945
Wnt5adecreases expressionISOWnt5a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of WNT5A mRNAPMID:17586704 PMID:19933214
Wnt5adecreases secretionISOWnt5a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased secretion of WNT5A proteinPMID:26572662
Wnt5aincreases expressionISOWNT5A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of WNT5A mRNA; Tetrachlorodibenzodioxin results in increased expression of WNT5A proteinPMID:19619570 PMID:21802500 PMID:22262711 PMID:28011154 PMID:36370075
Wnt5amultiple interactionsISOWNT5A (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of WNT5A mRNAPMID:19619570
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