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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69244
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcd2
Name: ATP binding cassette subfamily D member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcd2affects expressionISOAbcd2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ABCD2 mRNAPMID:21570461 PMID:28922406
Abcd2decreases expressionISOABCD2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNAPMID:20106945 PMID:26159488
Abcd2increases expressionISOAbcd2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCD2 mRNAPMID:21889950 PMID:25975270 PMID:28213091
Abcd2multiple interactionsISOABCD2 (Homo sapiens)6480464CTDEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNA]PMID:26159488
Abcd2multiple interactionsISOAbcd2 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ABCD2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABCD2 gene]PMID:25975270 PMID:28213091
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