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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69244
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcd2
Name: ATP binding cassette subfamily D member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7309686480464CTDTetrachlorodibenzodioxin affects the expression of ABCD2 mRNA

PMID:21570461, PMID:28922406
decreases expressionISORGD:7309676480464CTDTetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNA

PMID:20106945, PMID:26159488
increases expressionISORGD:7309686480464CTDTetrachlorodibenzodioxin results in increased expression of ABCD2 mRNA

PMID:21889950, PMID:25975270, PMID:28213091
multiple interactionsISORGD:7309676480464CTDEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNA]

PMID:26159488
multiple interactionsISORGD:7309686480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ABCD2 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABCD2 gene]

PMID:25975270, PMID:28213091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.