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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69238
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prss12
Name: serine protease 12
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prss12decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PRSS12 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Prss12increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PRSS12 genePMID:28505145
Prss12multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PRSS12 mRNAPMID:36041667
Prss12increases expressionISOPrss12 (Mus musculus)6480464CTDbisphenol A results in increased expression of PRSS12 mRNAPMID:30951980 PMID:32156529 PMID:34585602
Prss12multiple interactionsISOPRSS12 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRSS12 mRNAPMID:28628672
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