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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69226
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases expressionISOGpx4 (Mus musculus)6480464CTDBenzene results in decreased expression of GPX4 mRNA; Benzene results in decreased expression of GPX4 proteinPMID:35661779
Gpx4multiple interactionsISOGpx4 (Mus musculus)6480464CTDDeferoxamine inhibits the reaction [Benzene results in decreased expression of GPX4 mRNA]; Deferoxamine inhibits the reaction [Benzene results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GPX4 protein]PMID:35661779
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