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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69224
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx3
Name: glutathione peroxidase 3
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx3increases expressionISOGPX3 (Homo sapiens)6480464CTDDecitabine results in increased expression of GPX3 mRNAPMID:19194470
Gpx3multiple interactionsISOGPX3 (Homo sapiens)6480464CTD[Decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 mRNA; [Decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein; trichostatin A promotes the reaction [[Decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein]PMID:18664505
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