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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69224
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx3
Name: glutathione peroxidase 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of GPX3 mRNAPMID:26496021
Gpx3decreases expressionISOGpx3 (Mus musculus)6480464CTDEstradiol results in decreased expression of GPX3 mRNAPMID:11509743
Gpx3increases expressionISOGPX3 (Homo sapiens)6480464CTDEstradiol results in increased expression of GPX3 mRNA; Estradiol results in increased expression of GPX3 proteinPMID:18191855
Gpx3increases expressionISOGpx3 (Mus musculus)6480464CTDEstradiol results in increased expression of GPX3 mRNAPMID:11509743 PMID:18556351 PMID:19484750 PMID:19693291
Gpx3multiple interactionsISOGpx3 (Mus musculus)6480464CTD[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of GPX3 mRNA; [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of GPX3 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of GPX3 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of GPX3 mRNA; [Estradiol co-treated with Progesterone] results in increased expression of GPX3 mRNAPMID:11509743 PMID:18556351 PMID:19693291
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