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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2decreases expressionEXP 14981582RGDethanol decreases expression and activity of Aldh2 protein in rat liver 
Aldh2multiple interactionsEXP 15036805RGDethanol increases 4-hydroxynonenal-Aldh2 protein adduct formation; increases acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver 
Aldh2affects expressionEXP 6480464CTDEthanol affects the expression of ALDH2 proteinPMID:31550440
Aldh2affects response to substanceEXP 6480464CTDALDH2 protein affects the susceptibility to EthanolPMID:12439222
Aldh2increases activityEXP 6480464CTDEthanol results in increased activity of ALDH2 proteinPMID:23500772
Aldh2increases expressionEXP 6480464CTDEthanol results in increased expression of ALDH2 proteinPMID:23200777
Aldh2multiple interactionsEXP 6480464CTD[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]; [N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased susceptibility to Ethanol; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]]; Cyanamide affects the reaction [Ethanol affects the expression of ALDH2 protein]; Ethanol inhibits the reaction [Streptozocin results in decreased expression of ALDH2]PMID:19446252 PMID:23500772 PMID:31550440
Aldh2affects metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 gene polymorphism affects the metabolism of EthanolPMID:29923378
Aldh2affects response to substanceISOALDH2 (Homo sapiens)6480464CTDALDH2 gene polymorphism affects the susceptibility to Ethanol; ALDH2 gene SNP affects the susceptibility to Ethanol; ALDH2 protein affects the susceptibility to EthanolPMID:10780266 PMID:15840430 PMID:22960999 PMID:35713687
Aldh2decreases expressionISOAldh2 (Mus musculus)6480464CTDEthanol results in decreased expression of ALDH2 proteinPMID:35526736
Aldh2decreases response to substanceISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in decreased susceptibility to EthanolPMID:19429258
Aldh2increases activityISOAldh2 (Mus musculus)6480464CTDEthanol results in increased activity of ALDH2 proteinPMID:22022451
Aldh2increases expressionISOAldh2 (Mus musculus)6480464CTDEthanol results in increased expression of ALDH2 mRNAPMID:22554647 PMID:30319688
Aldh2increases expressionISOALDH2 (Homo sapiens)6480464CTDEthanol results in increased expression of ALDH2 mRNA; Ethanol results in increased expression of ALDH2 proteinPMID:19778255 PMID:22056336 PMID:35713687
Aldh2increases metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased metabolism of EthanolPMID:10064379 PMID:10826103
Aldh2increases response to substanceISOAldh2 (Mus musculus)6480464CTDALDH2 gene mutant form results in increased susceptibility to EthanolPMID:25155611 PMID:30721697
Aldh2increases response to substanceISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased susceptibility to EthanolPMID:15840430
Aldh2multiple interactionsISOAldh2 (Mus musculus)6480464CTD[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein; [Zinc co-treated with Ethanol] results in increased expression of ALDH2 mRNA; ALDH2 protein inhibits the reaction [Ethanol affects the abundance of Calcium]; ALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of NCF1 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of CREB1 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GATA4 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of MAP3K5 protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of ALDH2 protein]; taraxerone promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]PMID:17590987 PMID:19332462 PMID:19637192 PMID:20118189 PMID:22554647 PMID:35526736
Aldh2multiple interactionsISOALDH2 (Homo sapiens)6480464CTD[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein; [Plant Extracts results in increased abundance of Polyphenols] inhibits the reaction [Ethanol results in increased expression of ALDH2 protein]; ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of NOL3 protein]; ALDH2 protein inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of BAX protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein]; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of XIAP protein]; Ethanol results in decreased expression of and results in decreased activity of ALDH2 protein; HECTD4 protein inhibits the reaction [Ethanol results in increased expression of ALDH2 mRNA]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of ALDH2 protein]; NAD inhibits the reaction [[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein]; NAD inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of ALDH2 protein]; Resveratrol promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]; Silymarin inhibits the reaction [Ethanol results in increased expression of ALDH2 protein]PMID:19429258 PMID:19778255 PMID:22056336 PMID:35713687 PMID:37142061
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