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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69213
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR2
Name: estrogen receptor 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR2affects bindingEXP 6480464CTD[Estradiol binds to ESR2 protein] which binds to NCOA2 protein; ESR2 protein binds to Estradiol; Estradiol analog binds to ESR2 protein; Estradiol binds to ESR2 protein; Estradiol metabolite binds to ESR2 proteinPMID:10964929 PMID:11258963 PMID:11368622 PMID:11507064 PMID:11518614 PMID:12161000 PMID:12224631 PMID:12495555 PMID:12822488 PMID:14723943 PMID:15123288 PMID:15596252 PMID:15946813 PMID:15961563 PMID:16728493 PMID:16839579 PMID:17203231 PMID:19338011 PMID:19913605 PMID:20404318 PMID:20423157 PMID:22989670 PMID:23056236 PMID:25130739 PMID:25786527 PMID:28807876 PMID:29499249 PMID:30742918 PMID:31195007 PMID:31836225
ESR2affects localizationEXP 6480464CTDEstradiol affects the localization of ESR2 proteinPMID:31945389
ESR2affects response to substanceEXP 6480464CTDESR2 protein affects the susceptibility to EstradiolPMID:17275032
ESR2decreases expressionEXP 6480464CTDEstradiol results in decreased expression of ESR2 mRNA; Estradiol results in decreased expression of ESR2 mRNA alternative form; Estradiol results in decreased expression of ESR2 proteinPMID:15118252 PMID:15130599 PMID:16596234 PMID:18700809 PMID:18997820 PMID:27576059 PMID:29783106 PMID:31016752 PMID:31646340
ESR2increases activityEXP 6480464CTDEstradiol results in increased activity of ESR2 protein; Estradiol results in increased activity of ESR2 protein alternative formPMID:11335189 PMID:11875334 PMID:12387416 PMID:12402979 PMID:15064155 PMID:15103026 PMID:15171712 PMID:15319301 PMID:15537743 PMID:16118406 PMID:16756374 PMID:17266178 PMID:17935960 PMID:18486176 PMID:19161236 PMID:19584281 PMID:19654927 PMID:19672399 PMID:20049119 PMID:22613215 PMID:23892311 PMID:26139245 PMID:26778350 PMID:26812056 PMID:27592001 PMID:28248286 PMID:28571686 PMID:28701262 PMID:28704378 PMID:28717100 PMID:29421333 PMID:29601859 PMID:30017638 PMID:30582956 PMID:30818834 PMID:30951782 PMID:31381935 PMID:31388671
ESR2increases degradationEXP 6480464CTDEstradiol results in increased degradation of ESR2 proteinPMID:14702340
ESR2increases expressionEXP 6480464CTDEstradiol results in increased expression of ESR2 mRNA; Estradiol results in increased expression of ESR2 mRNA alternative form; Estradiol results in increased expression of ESR2 mRNA mutant form; Estradiol results in increased expression of ESR2 proteinPMID:12377985 PMID:12737316 PMID:14664715 PMID:15207704 PMID:15261991 PMID:16596234 PMID:16739346 PMID:18973785 PMID:20160136 PMID:20836126 PMID:23052036 PMID:23436777 PMID:23982890 PMID:26867312 PMID:28882636 PMID:29063134 PMID:29360751 PMID:29502166 PMID:29654831 PMID:31278978 PMID:34499926
ESR2increases localizationEXP 6480464CTDEstradiol results in increased localization of ESR2 proteinPMID:15171712
ESR2increases response to substanceEXP 6480464CTDESR2 protein results in increased susceptibility to EstradiolPMID:21732360
ESR2multiple interactionsEXP 6480464CTD1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Estradiol binds to ESR2 protein]; 1-hydroxypyrene inhibits the reaction [ESR2 protein binds to Estradiol]; 1-naphthol inhibits the reaction [ESR2 protein binds to Estradiol]; 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR2 protein]; 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; 22-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; 4,4'-bisphenol F inhibits the reaction [Estradiol binds to ESR2 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol binds to ESR2 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene affects the reaction [Estradiol binds to ESR2 protein]; 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR2 protein]; 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol inhibits the reaction [[Estradiol co-treated with ESR2] results in increased expression of NOS2 mRNA]; 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol inhibits the reaction [[Estradiol co-treated with ESR2] results in increased expression of NOS3 mRNA]; 9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol]; [(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; [4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol results in decreased activity of ESR2 protein] inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; [[aluminum chlorhydrate results in increased abundance of Aluminum] co-treated with [Tretinoin co-treated with Estradiol]] affects the localization of ESR2 protein; [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein; [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein; [ESR2 protein results in increased susceptibility to Estradiol] which results in increased expression of PTEN protein; [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to CST5 promoter]; [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to HAVCR2 promoter]; [Estradiol binds to ESR2 protein] which affects the folding of ESR2 protein; [Estradiol binds to ESR2 protein] which results in decreased expression of ADM mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of ASAP2 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of BMF mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of CCL3 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of CCL3L3 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of CLCF1 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of CXCL8 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of DMBT1 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of FGF2 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of IGSF9 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of KLF6 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of MYC mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of PKP2 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of PLAU mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of PLEKHF1 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of TGFB2 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of TNFRSF21 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of TRIB1 mRNA; [Estradiol binds to ESR2 protein] which results in decreased expression of ZFP36L1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ABCA3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ACVR1C mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of AFF1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of AGAP4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of AKAP1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ANXA8L1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of APOBEC1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ARHGAP18 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ARHGAP36 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ASB13 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ASCL1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ATP6V1C2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of B3GNT6 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of BCL7A mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of BIRC3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of BMP4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of BPIFB1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of BRI3BP mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of C14ORF132 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of C14ORF180 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of C3ORF70 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CABLES2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CACNA2D2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CACNB4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CALCR mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CASP7 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CASQ2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CD22 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CD83 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CDH26 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CGN mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CHPT1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CLASP2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CLCNKA mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CMKLR1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CPN2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CRKL mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CYP1A2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CYP46A1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of CYP4F11 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of DHRS9 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of DNAJA4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of DPEP3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of EGR2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FAM222A mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FGD5 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FGF3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FGFBP2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FGFR3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FGR mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FKBP4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FOXK1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of FUT4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GCH1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GCOM1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GHRHR mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GJB3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GPRIN2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GREB1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of GRTP1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of HAR1A mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of HDAC4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of HOMER2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of HSD11B2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ID2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of IGSF11 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of IL17RB mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of IL24 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of INPP5A mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of KAZN mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of KCNF1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of KCNK6 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of KRT74 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of LILRB5 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of LOX mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of LPAR1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of LPL mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of LRP5L mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of LRRC74A mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MAD1L1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MAG mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MANEAL mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MBOAT1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MCF2L2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MED12L mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of METRNL mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MGAT3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MLPH mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MRAP2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MUC1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MYB mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MYL10 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MYLK3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MYOG mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MYOT mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of MYT1L mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NCOA1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NEFH mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NHERF1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NHERF2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NPR2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NRIP1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of NTN4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ONECUT2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of OPRL1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of OSBPL5 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of OTOF mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PAPPA mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PAPSS2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PDE4B mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PDE4C mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PDZK1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PGAP4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PITX1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PKD2L1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PLA2G4D mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PLK2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PLOD2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of POM121L8P mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PTGER3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of PTH1R mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RAB36 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RAET1L mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RCAN1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RGL1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RGS19 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RNF14 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RNF144B mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RPS6KA2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of RUNX3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of S1PR1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of S1PR3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SATB2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SDC4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SH2D3C mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SLC16A3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SLC25A19 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SLC25A42 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SLC6A3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SLCO2A1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SLITRK4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SMTNL2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SNX24 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SOCS1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SOX2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SPIRE2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ST3GAL1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of STAT4 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SYNDIG1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SYNE3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of SYTL5 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TANK mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TAS1R1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TBKBP1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TCF21 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TESK2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TIMP3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TIPARP mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TLN2 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TMEM121B mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TMEM132C mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TP53I3 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TPPP mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TUBA3C mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TUBA3D mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of TUBA3E mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of UBASH3A mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of UNKL mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of UPF1 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of VPS8 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of VXN mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ZBTB5 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ZNF114 mRNA; [Estradiol binds to ESR2 protein] which results in increased expression of ZSWIM5 mRNA; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in decreased expression of ESR2 protein; [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of ESR2 mRNA; [Estradiol co-treated with ESR2 protein] results in decreased expression of EGFR mRNA; [Estradiol co-treated with ESR2 protein] results in decreased expression of EGFR protein; [Estradiol co-treated with ESR2 protein] results in increased expression of BGLAP mRNA; [Estradiol co-treated with ESR2 protein] results in increased expression of BSP mRNA; [Estradiol co-treated with ESR2 protein] results in increased expression of LTF mRNA; [Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; [Estradiol co-treated with ESR2] results in decreased expression of LOX mRNA; [Estradiol co-treated with ESR2] results in decreased expression of MCP1 protein; [Estradiol co-treated with ESR2] results in decreased expression of PDGFB mRNA; [Estradiol co-treated with ESR2] results in increased expression of NOS2 mRNA; [Estradiol co-treated with ESR2] results in increased expression of NOS3 mRNA; [Estradiol results in increased activity of ESR2 protein] which results in increased expression of IGFBP4 mRNA; [Estradiol results in increased activity of ESR2 protein] which results in increased expression of MT2A mRNA; [Tretinoin co-treated with Estradiol] affects the localization of ESR2 protein; [trichostatin A co-treated with Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 protein; [trichostatin A co-treated with Estradiol] results in increased expression of ESR2 mRNA; [trichostatin A co-treated with Estradiol] results in increased expression of ESR2 protein; Acriflavine inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; AHR protein inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; angelicae sinensis extract inhibits the reaction [Estradiol binds to ESR2 protein]; Apigenin inhibits the reaction [Estradiol binds to ESR2 protein]; benzyl benzoate inhibits the reaction [Estradiol binds to ESR2 protein]; benzyl salicylate inhibits the reaction [Estradiol binds to ESR2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]; beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]; bisphenol A analog inhibits the reaction [Estradiol binds to and results in increased activity of ESR2 protein]; bisphenol A analog inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; bisphenol A inhibits the reaction [Estradiol binds to ESR2 protein]; bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR2 protein]; bisphenol B inhibits the reaction [Estradiol binds to ESR2 protein]; bisphenol B inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; bisphenol C inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Bortezomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR2 protein]; butylbenzyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Butyric Acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]; carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Chlordecone inhibits the reaction [Estradiol binds to ESR2 protein]; citral inhibits the reaction [Estradiol binds to ESR2 protein]; Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein]; Cycloheximide promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]; daidzein inhibits the reaction [Estradiol binds to ESR2 protein]; daidzein promotes the reaction [Estradiol results in increased activity of ESR2 protein]; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; di-n-octyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Dibutyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; dicyclohexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Dieldrin promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]; Diethylhexyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR2 protein]; diisobutyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; diisononyl 1,2-cyclohexanedicarboxylic acid inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; diisononyl 1,2-cyclohexanedicarboxylic acid metabolite inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Endosulfan promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]; ESR2 affects the reaction [Estradiol affects the expression of ESR1 mRNA]; ESR2 affects the reaction [Estradiol results in increased expression of KRT19 mRNA]; ESR2 protein affects the reaction [Estradiol affects the expression of CCNA2 mRNA]; ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to NKD1 gene]]; ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]]; ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]]; ESR2 protein affects the reaction [Estradiol results in decreased expression of CDKN1A mRNA]; ESR2 protein affects the reaction [Estradiol results in decreased expression of FGFR2 mRNA]; ESR2 protein affects the reaction [Estradiol results in decreased expression of PTPRO mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of BCL2 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of CCN5 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of IL24 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of KLK3 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of KRT19 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of MMP12 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of PDCD4 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of RLN2 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of SMOX mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of TANK mRNA]; ESR2 protein promotes the reaction [Estradiol results in decreased abundance of Reactive Oxygen Species]; ESR2 protein promotes the reaction [Estradiol results in decreased expression of ITPR1 mRNA]; ESR2 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; ESR2 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Estradiol affects the reaction [daidzein metabolite affects the activity of ESR2 protein]; Estradiol affects the reaction [Equol affects the activity of ESR2 protein]; Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein]; Estradiol affects the reaction [O-desmethylangolensin affects the activity of ESR2 protein]; Estradiol affects the reaction [Quercetin results in increased activity of ESR2 protein]; Estradiol affects the reaction [tetrahydrodaidzein affects the activity of ESR2 protein]; Estradiol binds to and affects the folding of and results in increased activity of ESR2 protein; Estradiol binds to and results in increased activity of ESR2 protein; Estradiol inhibits the reaction [ESR2 protein affects the expression of CDK5R1 mRNA]; Estradiol inhibits the reaction [ESR2 protein affects the expression of TRIM47 mRNA]; Estradiol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]; Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; Estradiol promotes the reaction [ESR1 protein binds to ESR2 protein]; Estradiol promotes the reaction [ESR2 protein affects the expression of ADAMTSL5 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of ANO1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of ARHGEF39 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of ATP8B3 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CA12 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CACNA1I mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CASP7 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CD34 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CHST8 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CLEC4M mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of COL15A1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of COL18A1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CRISPLD2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CST1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CST5 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of CYP19A1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of ELF3 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of FGD6 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of FIGNL2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of GABBR2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of GALNT12 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of GCOM1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of GREB1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of HAVCR2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of HOXD10 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of HSPB8 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of KIF21A mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of KRT13 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of KRT15 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of KRT19 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of KRT72 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of KRT86 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of MDFIC mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of METRNL mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of MXD1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of NAV2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of NPR2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of OTOF mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of PADI4 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of PDK4 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of PTGER3 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of RGS10 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SEMA3F mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SH2D3C mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SLC25A42 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SLC45A3 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SLC47A2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SLC6A6 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SPOCD1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of STOX2 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of SYBU mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of TAS1R1 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of TH mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of TNFSF14 mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of TUBA3D mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of VASN mRNA]; Estradiol promotes the reaction [ESR2 protein affects the expression of ZFP36 mRNA]; Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR2 protein alternative form]; Estradiol promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Estradiol promotes the reaction [ESR2 protein binds to ESR2 protein]; Estradiol promotes the reaction [ESR2 protein binds to EZH2 promoter]; Estradiol promotes the reaction [ESR2 protein binds to HOXA10 promoter]; Estradiol promotes the reaction [ESR2 protein binds to IGF1 promoter]; Estradiol promotes the reaction [ESR2 protein binds to KRT19 promoter]; Estradiol promotes the reaction [ESR2 protein binds to NCOA1 protein]; Estradiol promotes the reaction [ESR2 protein binds to NCOA2 protein]; Estradiol promotes the reaction [ESR2 protein binds to NKD1 gene]; Estradiol promotes the reaction [ESR2 protein binds to PTGS2 promoter]; Estradiol promotes the reaction [ESR2 protein binds to TMEM121B gene]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of ADORA2B mRNA]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of IL6 mRNA]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of INHBE mRNA]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of NOG mRNA]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of PDE5A mRNA]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of SERTAD4 mRNA]; Estradiol promotes the reaction [ESR2 protein results in decreased expression of SHOC1 mRNA]; Estradiol promotes the reaction [NCOA1 protein binds to ESR2 protein]; Estradiol promotes the reaction [SRA1 protein binds to ESR2 protein]; Estradiol results in increased activity of [ESR1 protein co-treated with ESR2 protein]; Estradiol results in increased phosphorylation of and results in increased localization of and results in increased activity of ESR2 protein; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]; Eugenol inhibits the reaction [Estradiol binds to ESR2 protein]; fenarimol promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]; fenpyroximate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein]; fludioxonil inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; fluorene-9-bisphenol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; fluoxastrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased localization of ESR2 protein]; Fulvestrant inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; Genistein inhibits the reaction [Estradiol binds to ESR2 protein]; Genistein promotes the reaction [Estradiol results in increased activity of ESR2 protein]; geraniol inhibits the reaction [Estradiol binds to ESR2 protein]; hexabrominated diphenyl ether 153 inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; kaempferol inhibits the reaction [Estradiol binds to ESR2 protein]; kresoxim-methyl inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Lycopene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein]; mono-benzyl phthalate promotes the reaction [Estradiol results in increased activity of ESR2 protein]; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; naringenin inhibits the reaction [Estradiol binds to ESR2 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; perfluorooctane sulfonic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]; perfluorooctanoic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Phytoestrogens inhibits the reaction [Estradiol binds to ESR2 protein]; picoxystrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Plant Extracts inhibits the reaction [Estradiol binds to ESR2 protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Polychlorinated Biphenyls metabolite inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; prochloraz promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]; Propolis inhibits the reaction [Estradiol binds to ESR2 protein]; pyridaben inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Quercetin promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Raloxifene Hydrochloride promotes the reaction [[trichostatin A co-treated with Estradiol] results in increased expression of ESR2 mRNA]; Resveratrol inhibits the reaction [Estradiol binds to ESR2 protein]; Resveratrol promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Rotenone inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein]; Sodium Hypochlorite inhibits the reaction [Estradiol binds to ESR2 protein]; ST 1481 inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Cycloheximide promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA mutant form]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Topotecan inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; tri-(2-ethylhexyl)trimellitate promotes the reaction [Estradiol results in increased activity of ESR2 protein]; trichostatin A promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Triclosan inhibits the reaction [Estradiol binds to ESR2 protein]; trifloxystrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; triphenyl phosphate metabolite inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Valproic Acid metabolite promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Valproic Acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]PMID:10964929 PMID:11258963 PMID:11368622 PMID:11507064 PMID:11583108 PMID:12377985 PMID:12399409 PMID:12495555 PMID:12822488 PMID:14699072 PMID:14709801 PMID:14723943 PMID:14742696 PMID:15103026 PMID:15130599 PMID:15171712 PMID:15207704 PMID:15236964 PMID:15261991 PMID:15937998 PMID:15946813 PMID:16079615 PMID:16118406 PMID:16216903 PMID:16566672 PMID:16756374 PMID:16938840 PMID:16965913 PMID:17051425 PMID:17131305 PMID:17135255 PMID:17287592 PMID:17713618 PMID:17872375 PMID:17872378 PMID:17873880 PMID:17935960 PMID:17962382 PMID:17992702 PMID:18486176 PMID:18973785 PMID:19095770 PMID:19264808 PMID:19338011 PMID:19347870 PMID:19426747 PMID:19434490 PMID:19654927 PMID:19672399 PMID:20061804 PMID:20160136 PMID:20332105 PMID:20372779 PMID:20404318 PMID:20427257 PMID:20463317 PMID:20623183 PMID:20836126 PMID:21218783 PMID:21622942 PMID:21732360 PMID:21783566 PMID:22476901 PMID:22507746 PMID:22613215 PMID:22989670 PMID:23056236 PMID:23436777 PMID:23567241 PMID:23857583 PMID:23892311 PMID:25088689 PMID:25752796 PMID:25786527 PMID:26778350 PMID:26867312 PMID:28248286 PMID:28571686 PMID:28717100 PMID:28807876 PMID:28882636 PMID:29421333 PMID:29601859 PMID:29654831 PMID:30582956 PMID:30818834 PMID:31016752 PMID:31195007 PMID:31646340 PMID:31945389 PMID:34499926 PMID:35747940 PMID:36142876 PMID:36513145 PMID:9751507
ESR2affects bindingISOEsr2 (Mus musculus)6480464CTDEstradiol binds to ESR2 proteinPMID:19913605 PMID:21278053
ESR2affects bindingISOEsr2 (Rattus norvegicus)6480464CTDEstradiol binds to ESR2 protein; Estradiol binds to ESR2 protein alternative formPMID:10619402 PMID:11014220 PMID:15458795 PMID:19913605 PMID:20132880 PMID:9492041
ESR2affects expressionISOEsr2 (Rattus norvegicus)6480464CTDEstradiol affects the expression of ESR2 mRNA; Estradiol affects the expression of ESR2 proteinPMID:22389237 PMID:27463640
ESR2affects localizationISOEsr2 (Rattus norvegicus)6480464CTDEstradiol affects the localization of ESR2 proteinPMID:19479021 PMID:22070562
ESR2affects response to substanceISOEsr2 (Mus musculus)6480464CTDESR2 protein affects the susceptibility to EstradiolPMID:11145618
ESR2decreases expressionISOEsr2 (Mus musculus)6480464CTDEstradiol results in decreased expression of ESR2 mRNA; Estradiol results in decreased expression of ESR2 proteinPMID:11509743 PMID:17850458 PMID:20574910 PMID:28476547
ESR2decreases expressionISOEsr2 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of ESR2 mRNA; Estradiol results in decreased expression of ESR2 proteinPMID:12008023 PMID:12834913 PMID:15458795 PMID:15458797 PMID:15548368 PMID:15979666 PMID:16414171 PMID:16522720 PMID:16614383 PMID:17532555 PMID:19479021 PMID:20381596 PMID:25008887
ESR2increases activityISOEsr2 (Mus musculus)6480464CTDEstradiol results in increased activity of ESR2 proteinPMID:19495926
ESR2increases activityISOEsr2 (Rattus norvegicus)6480464CTDEstradiol results in increased activity of ESR2 proteinPMID:11583108 PMID:14662790 PMID:15901789 PMID:22166976 PMID:9860891
ESR2increases expressionISOEsr2 (Mus musculus)6480464CTDEstradiol results in increased expression of ESR2 mRNA; Estradiol results in increased expression of ESR2 protein; Estradiol results in increased expression of ESR2 protein alternative formPMID:14664715 PMID:15916834 PMID:16606610 PMID:17089059 PMID:18281260 PMID:19279558 PMID:22056370 PMID:27634370 PMID:28356238 PMID:29360751 PMID:30196065 PMID:31225646
ESR2increases expressionISOEsr2 (Rattus norvegicus)6480464CTDEstradiol results in increased expression of ESR2 mRNA; Estradiol results in increased expression of ESR2 proteinPMID:15458797 PMID:16311018 PMID:19094096 PMID:21127968 PMID:22070562
ESR2multiple interactionsISOEsr2 (Mus musculus)6480464CTD4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of ESR2 mRNA; [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of ESR2 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR2 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of ESR2 mRNA; beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR2 protein]; bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; bu-zhong-yi-qi-tang inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Dieldrin inhibits the reaction [Estradiol binds to ESR2 protein]; Endosulfan inhibits the reaction [Estradiol binds to ESR2 protein]; ESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA]; ESR2 affects the reaction [Estradiol results in decreased expression of ESR1 protein]; ESR2 affects the reaction [Estradiol results in increased expression of PGR protein]; ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Estradiol]; ESR2 protein alternative form inhibits the reaction [Estradiol results in increased expression of ESR2 protein]; ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]; Estradiol binds to and affects the activity of ESR2 protein alternative form; Estradiol inhibits the reaction [ESR2 protein alternative form results in increased expression of GNRH1 mRNA]; Estradiol inhibits the reaction [fulvestrant results in decreased expression of ESR2 mRNA alternative form]; fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; NCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]; NCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein]; NCOA2 protein inhibits the reaction [ESR2 protein alternative form inhibits the reaction [Estradiol results in increased expression of ESR2 protein]]; NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]; NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein]; NCOA3 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]; Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]PMID:11145618 PMID:11509743 PMID:12834440 PMID:15924412 PMID:16439454 PMID:17089059 PMID:17974624 PMID:20378682 PMID:21278053 PMID:22056370 PMID:27634370 PMID:28356238 PMID:28476547
ESR2multiple interactionsISOEsr2 (Rattus norvegicus)6480464CTD2,2',4,4',5-brominated diphenyl ether promotes the reaction [Estradiol results in decreased expression of ESR2 mRNA]; 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA]; [Arsenic co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of ESR2 mRNA; [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in increased expression of ESR2 mRNA; [enzacamene co-treated with Estradiol co-treated with Triiodothyronine] affects the expression of ESR2 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of ESR2 mRNA; [Estradiol co-treated with Tamoxifen] results in increased expression of ESR2 protein; [Estradiol co-treated with Triiodothyronine] inhibits the reaction [bisphenol A results in decreased expression of ESR2 mRNA]; [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA]; [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Androstane-3,17-diol inhibits the reaction [Estradiol binds to ESR2 protein]; bisphenol A inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR2 protein]; ESR1 protein results in decreased susceptibility to [Estradiol co-treated with ESR2 protein]; ESR2 protein affects the reaction [Estradiol results in increased expression of SLC6A3 protein]; Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR2 mRNA]; Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR2 protein]; Estradiol binds to and results in increased activity of ESR2 protein; Estradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estradiol inhibits the reaction [Estrogens deficiency results in increased expression of ESR2 protein alternative form]; Estradiol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR2 mRNA]; Estradiol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR2 protein]; Estradiol promotes the reaction [[ESR2 protein binds to FHL1 promoter] which results in decreased expression of FHL1 mRNA]; Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR1 protein]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein]; Genistein inhibits the reaction [Estradiol affects the expression of ESR2 mRNA]; Genistein inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Progesterone inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Tamoxifen inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR2 protein]PMID:11014220 PMID:11583108 PMID:16414171 PMID:16451217 PMID:17049845 PMID:19094096 PMID:19460436 PMID:20149813 PMID:21277368 PMID:22166976 PMID:22389237 PMID:24333797 PMID:27338438 PMID:30565903 PMID:8650195 PMID:9048584 PMID:9492041
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