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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69213
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR2
Name: estrogen receptor 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR2affects bindingEXP 6480464CTDQuercetin binds to ESR2 proteinPMID:12224631 PMID:14706564 PMID:19913605
ESR2decreases expressionEXP 6480464CTDQuercetin results in decreased expression of ESR2 mRNAPMID:32530119
ESR2increases activityEXP 6480464CTDQuercetin results in increased activity of ESR2 proteinPMID:16118406 PMID:18955141 PMID:22613215
ESR2increases expressionEXP 6480464CTDQuercetin results in increased expression of ESR2 mRNA; Quercetin results in increased expression of ESR2 proteinPMID:15182386 PMID:24299158 PMID:36982678
ESR2increases response to substanceEXP 6480464CTDESR2 protein results in increased susceptibility to QuercetinPMID:21732360
ESR2multiple interactionsEXP 6480464CTD[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein; [ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein; [ESR2 protein results in increased susceptibility to Quercetin] which results in increased expression of PTEN protein; Estradiol affects the reaction [Quercetin results in increased activity of ESR2 protein]; Quercetin binds to and results in increased activity of ESR2 protein; Quercetin promotes the reaction [Estradiol results in increased activity of ESR2 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; Tamoxifen promotes the reaction [Quercetin results in decreased expression of ESR2 mRNA]PMID:11502892 PMID:15182386 PMID:15937998 PMID:16118406 PMID:21732360 PMID:22613215 PMID:32530119 PMID:9751507
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