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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69210
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7A1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNAPMID:20106945
CYP7A1multiple interactionsEXP 6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP7A1 mRNAPMID:26159488
CYP7A1decreases expressionISOCyp7a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNAPMID:19770486 PMID:21846477 PMID:28213091
CYP7A1decreases expressionISOCyp7a1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNAPMID:16054898 PMID:21215274
CYP7A1increases expressionISOCyp7a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP7A1 mRNAPMID:21095216
CYP7A1increases expressionISOCyp7a1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP7A1 mRNAPMID:32109520
CYP7A1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP7A1 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP7A1 mRNA; [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP7A1 gene]PMID:23756648 PMID:28213091 PMID:28433925 PMID:30722647
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