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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69210
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7A1decreases expressionEXP 6480464CTDLithocholic Acid results in decreased expression of CYP7A1 mRNAPMID:25055961
CYP7A1multiple interactionsEXP 6480464CTD[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNAPMID:17963371
CYP7A1decreases activityISOCyp7a1 (Rattus norvegicus)6480464CTDLithocholic Acid results in decreased activity of CYP7A1 proteinPMID:1175606
CYP7A1decreases expressionISOCyp7a1 (Mus musculus)6480464CTDLithocholic Acid results in decreased expression of CYP7A1 mRNAPMID:16436656 PMID:19196849 PMID:20359477 PMID:20671298 PMID:22982774 PMID:23034213 PMID:25582706
CYP7A1decreases expressionISOCyp7a1 (Rattus norvegicus)6480464CTDLithocholic Acid results in decreased expression of CYP7A1 mRNAPMID:20888898
CYP7A1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTD1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]PMID:19196849 PMID:20359477 PMID:22531947
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