GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | Methotrexate results in decreased expression of PPARG mRNA; Methotrexate results in decreased expression of PPARG protein | PMID:28414158 PMID:34737150 PMID:36249937 PMID:37341015 | Pparg | increases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | Methotrexate results in increased expression of PPARG protein | PMID:25187349 | Pparg | multiple interactions | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]]; [Methotrexate co-treated with Leucovorin] results in increased expression of PPARG mRNA; [Methotrexate co-treated with Leucovorin] results in increased expression of PPARG protein; Buspirone inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG protein] | PMID:25187349 PMID:28414158 PMID:34737150 PMID:36249937 PMID:37341015 | | ||||||||||||||||||||||
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