GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | EXP | | 6480464 | CTD | Tamoxifen results in decreased expression of PPARG protein | PMID:27358406 | Pparg | increases expression | EXP | | 6480464 | CTD | Tamoxifen results in increased expression of PPARG mRNA | PMID:25123088 | Pparg | multiple interactions | EXP | | 6480464 | CTD | PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; PPARG mRNA promotes the reaction [Tamoxifen results in decreased expression of CD36 mRNA]; PPARG mRNA promotes the reaction [Tamoxifen results in decreased expression of CD36 protein]; Tamoxifen binds to and results in decreased activity of PPARG protein | PMID:27358406 PMID:33049310 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Tamoxifen inhibits the reaction [PPARG protein binds to CD36 promoter]; Tamoxifen inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; Tamoxifen results in decreased expression of and results in increased phosphorylation of PPARG protein | PMID:27358406 | | ||||||||||||||||||||||
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