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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:35033
Term: triphenyl phosphate
Definition: An aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol.
Chemical ID: MESH:C005445
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionEXP 6480464CTDtriphenyl phosphate results in increased expression of PPARG mRNAPMID:28163246
Ppargmultiple interactionsEXP 6480464CTD[triphenyl phosphate co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA; [tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of PPARG mRNA; [tris(1,3-dichloro-2-propyl)phosphate co-treated with Tritolyl Phosphates co-treated with triphenyl phosphate] results in increased expression of PPARG mRNA; triphenyl phosphate binds to and results in increased activity of PPARG proteinPMID:29112739 PMID:32360330 PMID:33049310 PMID:34323617
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDtriphenyl phosphate binds to PPARG protein; triphenyl phosphate metabolite binds to PPARG proteinPMID:25062436 PMID:25314719
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDtriphenyl phosphate results in increased activity of PPARG proteinPMID:26172262 PMID:28282128 PMID:28728110
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDtriphenyl phosphate results in increased expression of PPARG mRNAPMID:25062436 PMID:28934090
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of PPARG mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of PPARG mRNA; PPARG protein affects the reaction [triphenyl phosphate results in increased expression of HSD3B1 mRNA]; triphenyl phosphate binds to and results in decreased expression of PPARG protein; triphenyl phosphate binds to and results in increased activity of PPARG proteinPMID:28282128 PMID:28437481 PMID:30966736 PMID:33049310
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