Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDGenistein results in decreased expression of PPARG mRNAPMID:18359623
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDGenistein results in decreased expression of PPARG mRNAPMID:20706672
Ppargincreases activityISOPparg (Rattus norvegicus)6480464CTDGenistein results in increased activity of PPARG proteinPMID:19903033
Ppargincreases expressionISOPparg (Rattus norvegicus)6480464CTDGenistein results in increased expression of PPARG mRNAPMID:24361872
Ppargmultiple interactionsISOPparg (Rattus norvegicus)6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Genistein results in increased activity of PPARG protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Genistein results in increased activity of PPARG protein]; Genistein inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Genistein inhibits the reaction [Dietary Fats results in increased expression of PPARG protein]PMID:19903033 PMID:27171397
Go Back to source page   Continue to Ontology report