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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGdecreases activityEXP 6480464CTDochratoxin A results in decreased activity of PPARG proteinPMID:20590410 PMID:27481073
PPARGdecreases expressionEXP 6480464CTDochratoxin A results in decreased expression of PPARGPMID:20590410
PPARGincreases expressionEXP 6480464CTDochratoxin A results in increased expression of PPARG mRNAPMID:32905824
PPARGincreases phosphorylationEXP 6480464CTDochratoxin A results in increased phosphorylation of PPARG proteinPMID:20590410
PPARGincreases expressionISOPparg (Rattus norvegicus)6480464CTDochratoxin A results in increased expression of PPARG mRNAPMID:15994020
PPARGmultiple interactionsISOPparg (Rattus norvegicus)6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]PMID:15994020
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