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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGaffects expressionEXP 6480464CTDDiclofenac affects the expression of PPARG mRNAPMID:24752500
PPARGincreases activityEXP 6480464CTDDiclofenac results in increased activity of PPARG proteinPMID:12065695 PMID:15273253 PMID:28728110
PPARGmultiple interactionsEXP 6480464CTDDiclofenac inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]PMID:30138673
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