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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGaffects bindingEXP 6480464CTDDibutyl Phthalate binds to PPARG proteinPMID:23843199
PPARGincreases activityEXP 6480464CTDDibutyl Phthalate results in increased activity of PPARG proteinPMID:26172262
PPARGincreases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of PPARG proteinPMID:29061543
PPARGmultiple interactionsEXP 6480464CTDDibutyl Phthalate binds to and results in increased activity of PPARG proteinPMID:24155963 PMID:27633901 PMID:33049310
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTDDibutyl Phthalate binds to and results in increased activity of PPARG proteinPMID:33049310
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