GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PPARG | increases expression | EXP | | 6480464 | CTD | Palmitic Acid results in increased expression of PPARG protein | PMID:30208301 | PPARG | multiple interactions | EXP | | 6480464 | CTD | [Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG protein; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of PPARG mRNA; [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of PPARG protein; ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]]; Coptidis rhizoma extract inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA]; Coptidis rhizoma extract inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG protein]; Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of PPARG protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein] | PMID:30208301 PMID:32613381 PMID:36905866 PMID:38103844 | PPARG | decreases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | Palmitic Acid results in decreased expression of PPARG mRNA | PMID:25108154 | PPARG | increases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Palmitic Acid results in increased expression of PPARG mRNA; Palmitic Acid results in increased expression of PPARG protein | PMID:18154422 PMID:30208301 PMID:37271273 | PPARG | multiple interactions | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | [Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [Ethanol results in increased expression of PPARG mRNA]; [Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA; AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]; Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]; Resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]; Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]; tetrabromobisphenol A inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA]; Triiodothyronine inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA] | PMID:25048947 PMID:25108154 PMID:26190035 PMID:26854922 | PPARG | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [Palmitic Acid co-treated with Ethanol] results in increased expression of PPARG mRNA; [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of PPARG mRNA; [sodium arsenite co-treated with Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of PPARG mRNA; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein] | PMID:30208301 PMID:34968464 PMID:37271273 | | ||||||||||||||||||||||
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