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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69152
Species: Homo sapiens
RGD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:28885
Term: butan-1-ol
Definition: A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
Chemical ID: MESH:D020001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFRmultiple interactionsISOEgfr (Rattus norvegicus)6480464CTD1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; 1-Butanol inhibits the reaction [EGF protein binds to and results in increased degradation of EGFR protein]; 1-Butanol inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein]PMID:11134345 PMID:15525798
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