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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69148
Species: Homo sapiens
RGD Object: Gene
Symbol: NFIC
Name: nuclear factor I C
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFICaffects localizationISONfic (Mus musculus)6480464CTDZinc deficiency affects the localization of NFIC proteinPMID:22228435
NFICdecreases expressionISONfic (Mus musculus)6480464CTDZinc results in decreased expression of NFIC mRNA; Zinc results in decreased expression of NFIC proteinPMID:22228435
NFICmultiple interactionsISONfic (Mus musculus)6480464CTD[Zinc deficiency promotes the reaction [NFIC protein binds to SLC39A13 protein]] which results in decreased expression of SLC39A13 mRNA; Zinc deficiency promotes the reaction [NFIC protein binds to SLC39A13 protein]; Zinc inhibits the reaction [NFIC protein binds to DSPP promoter]; Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein]PMID:22228435
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