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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9decreases expressionEXP 6480464CTDFluorouracil results in decreased expression of CASP9 mRNAPMID:23941782
CASP9increases activityEXP 6480464CTDFluorouracil results in increased activity of CASP9 proteinPMID:10779637 PMID:12414664 PMID:15996812 PMID:16407826 PMID:16803524 PMID:17056233 PMID:18830594
CASP9increases cleavageEXP 6480464CTDFluorouracil results in increased cleavage of CASP9 proteinPMID:17498489 PMID:19816940
CASP9increases expressionEXP 6480464CTDFluorouracil results in increased expression of CASP9 proteinPMID:16803524
CASP9multiple interactionsEXP 6480464CTD[Docosahexaenoic Acids co-treated with Fluorouracil] results in decreased expression of CASP9 mRNA; [Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; [Fluorouracil co-treated with Cisplatin] results in increased activity of CASP9 protein; [Fluorouracil co-treated with Cisplatin] results in increased expression of CASP9 protein; Cadmium Chloride promotes the reaction [Fluorouracil results in decreased expression of CASP9 mRNA]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 mRNA]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Arsenic Trioxide results in decreased expression of CASP9 protein]; Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein; IFNA1 protein promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein]; PTGS2 protein inhibits the reaction [Fluorouracil results in increased activity of CASP9 protein]; RNF34 protein inhibits the reaction [Fluorouracil results in increased activity of CASP9 protein]; TP53 protein inhibits the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein]; TP53 protein inhibits the reaction [N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein]]PMID:12414664 PMID:15546879 PMID:16168113 PMID:16407826 PMID:16803524 PMID:17016659 PMID:17056233 PMID:19015929 PMID:19097688 PMID:19928967 PMID:22963400 PMID:23941782
CASP9increases activityISOCasp9 (Mus musculus)6480464CTDFluorouracil results in increased activity of CASP9 proteinPMID:28025107 PMID:32270916
CASP9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTDFluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein]PMID:31129132
CASP9multiple interactionsISOCasp9 (Mus musculus)6480464CTDApigenin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; casticin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP9 protein]PMID:28025107 PMID:32270916
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