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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69141
Species: Mus musculus
RGD Object: Gene
Symbol: Smad7
Name: SMAD family member 7
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad7decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of SMAD7 mRNAPMID:25912033
Smad7increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of SMAD7 mRNAPMID:25827057
Smad7multiple interactionsEXP 6480464CTDSMAD7 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein]PMID:17657819
Smad7decreases expressionISOSmad7 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of SMAD7 mRNA; Carbon Tetrachloride results in decreased expression of SMAD7 proteinPMID:16872305 PMID:17163593 PMID:24211420 PMID:30254303 PMID:31150632
Smad7increases expressionISOSmad7 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of SMAD7 mRNAPMID:12445421
Smad7increases methylationISOSmad7 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased methylation of SMAD7 promoterPMID:24211420
Smad7multiple interactionsISOSmad7 (Rattus norvegicus)6480464CTDCarvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]; Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]; Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]; pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]PMID:12445421 PMID:16872305 PMID:17163593 PMID:30254303 PMID:31150632
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