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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69127
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl5increases expressionEXP 6480464CTDPoly I-C results in increased expression of CCL5 mRNAPMID:25780039
Ccl5increases secretionEXP 6480464CTDPoly I-C results in increased secretion of CCL5 proteinPMID:24056979
Ccl5multiple interactionsEXP 6480464CTDAPPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL5 protein]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]PMID:24056979 PMID:25780039
Ccl5increases expressionISOCCL5 (Homo sapiens)6480464CTDPoly I-C results in increased expression of CCL5; Poly I-C results in increased expression of CCL5 mRNAPMID:23688403 PMID:24709138
Ccl5multiple interactionsISOCCL5 (Homo sapiens)6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of CCL5]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of CCL5]PMID:23688403 PMID:24709138
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