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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69127
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl5increases expressionEXP 6480464CTDCisplatin results in increased expression of CCL5 mRNA; Cisplatin results in increased expression of CCL5 proteinPMID:15814532 PMID:20702592 PMID:21151649
Ccl5multiple interactionsEXP 6480464CTD[Cisplatin co-treated with TNF protein] results in increased expression of CCL5 mRNA; pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCL5 mRNA]; pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCL5 protein]; TIMD2 promotes the reaction [Cisplatin results in increased expression of CCL5 mRNA]PMID:15814532 PMID:20702592 PMID:23103562
Ccl5affects expressionISOCcl5 (Rattus norvegicus)6480464CTDCisplatin affects the expression of CCL5 proteinPMID:25051504
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