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GENE - TERM ANNOTATION REPORT

RGD ID: 69123
Species: Homo sapiens
RGD Object: Gene
Symbol: LEP
Name: leptin
Acc ID: GO:0033210
Term: leptin-mediated signaling pathway
Definition: The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
Definition Source(s): GOC:mah, GOC:signaling, GOC:yaf
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LEP ISOLep (Rattus norvegicus)9068941RGD PMID:9070213 PMID:9618284 REF_RGD_ID:2290293 REF_RGD_ID:2290294
LEPinvolved_inIEAUniProtKB:P41160 or UniProtKB:P50596 or ensembl:ENSMUSP00000067046 or ensembl:ENSRNOP00000066184150520179Ensembl GO_REF:0000107
LEPinvolved_inISSUniProtKB:P41160 or UniProtKB:P50596150520179UniProt GO_REF:0000024
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