GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | LEP | decreases expression | ISO | Lep (Mus musculus) | 6480464 | CTD | methylmercuric chloride results in decreased expression of LEP mRNA | PMID:29850906 | LEP | multiple interactions | ISO | Lep (Mus musculus) | 6480464 | CTD | [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein; LEP protein affects the reaction [methylmercuric chloride affects the expression of POMC mRNA]; LEP protein affects the reaction [methylmercuric chloride affects the expression of SOCS3 mRNA]; LEP protein affects the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]; LEP protein affects the reaction [methylmercuric chloride results in decreased expression of HMOX1 protein]; LEP protein affects the reaction [methylmercuric chloride results in decreased phosphorylation of MAPK1 protein]; LEP protein affects the reaction [methylmercuric chloride results in decreased phosphorylation of MAPK3 protein]; methylmercuric chloride promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] | PMID:27814245 PMID:33338554 | | ||||||||||||||||||||||
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