GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | LEP | multiple interactions | EXP | | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased activity of CASP3 protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]; [Estradiol co-treated with LEP protein] results in decreased expression of CASP3 mRNA; [Estradiol co-treated with LEP protein] results in decreased expression of CASP3 protein; Estradiol promotes the reaction [LEP protein results in decreased activity of CASP3 protein]; LEP protein promotes the reaction [Estradiol results in decreased activity of CASP3 protein] | PMID:23850738 | LEP | increases expression | ISO | Lep (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of LEP mRNA | PMID:26164745 | LEP | increases expression | ISO | Lep (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of LEP mRNA | PMID:18359623 | | ||||||||||||||||||||||
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