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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69116
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin dependent kinase inhibitor 1B
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bmultiple interactionsEXP 6480464CTDCDKN1B protein inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK2 protein]; CDKN1B results in decreased susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]PMID:17620307
Cdkn1bdecreases expressionISOCdkn1b (Rattus norvegicus)6480464CTDDiethylnitrosamine results in decreased expression of CDKN1B proteinPMID:17582756
Cdkn1bmultiple interactionsISOCdkn1b (Rattus norvegicus)6480464CTD2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA; [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDKN1B mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA; pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]]; pioglitazone promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]PMID:17582756 PMID:17602206 PMID:18253720 PMID:18544905
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