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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Bmultiple interactionsEXP 6480464CTDAKT1 protein affects the reaction [Vanadates inhibits the reaction [chromium hexavalent ion affects the localization of CDKN1B protein]]; AKT1 protein modified form inhibits the reaction [chromium hexavalent ion affects the localization of CDKN1B protein]; chromium hexavalent ion results in decreased expression of and affects the localization of CDKN1B protein; Vanadates inhibits the reaction [chromium hexavalent ion results in decreased expression of and affects the localization of CDKN1B protein]PMID:19377290
CDKN1Bincreases expressionISOCdkn1b (Rattus norvegicus)6480464CTDchromium hexavalent ion results in increased expression of CDKN1B proteinPMID:21621607 PMID:24530425
CDKN1Bmultiple interactionsISOCdkn1b (Mus musculus)6480464CTD[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN1B mRNAPMID:25820237
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