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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Bincreases expressionEXP 6480464CTDResveratrol results in increased expression of CDKN1B mRNA; Resveratrol results in increased expression of CDKN1B proteinPMID:15829497 PMID:16761963 PMID:17050787 PMID:17088997 PMID:17804756 PMID:18089832 PMID:18347188 PMID:20504360 PMID:21179458 PMID:21209944 PMID:21980390 PMID:22029423 PMID:24331535 PMID:25672876
CDKN1Bmultiple interactionsEXP 6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of CDKN1B mRNA; [Resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CDKN1B protein; FOXO1 protein affects the reaction [Resveratrol results in increased expression of CDKN1B protein]; FOXO3 protein affects the reaction [Resveratrol results in increased expression of CDKN1B protein]; FOXO4 protein affects the reaction [Resveratrol results in increased expression of CDKN1B protein]; Resveratrol inhibits the reaction [cudraflavone B results in increased expression of CDKN1B protein]; Resveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]; Resveratrol promotes the reaction [FOXO3 protein binds to CDKN1B promoter]PMID:17513867 PMID:18022818 PMID:21179458 PMID:23557933 PMID:23881456
CDKN1Bdecreases expressionISOCdkn1b (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of CDKN1B mRNAPMID:25905778
CDKN1Bincreases expressionISOCdkn1b (Mus musculus)6480464CTDresveratrol results in increased expression of CDKN1B proteinPMID:21980390
CDKN1Bmultiple interactionsISOCdkn1b (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]PMID:22561310
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