GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PDK4 | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of PDK4 mRNA; sodium arsenite results in decreased expression of PDK4 protein | PMID:27217333 PMID:29301061 PMID:34032870 | PDK4 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of PDK4 mRNA | PMID:23648393 | PDK4 | multiple interactions | EXP | | 6480464 | CTD | BRD4770 inhibits the reaction [sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter]]; sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 mRNA]; sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 protein]; sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter] | PMID:27217333 | PDK4 | decreases expression | ISO | Pdk4 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of PDK4 mRNA | PMID:31170414 | PDK4 | multiple interactions | ISO | Pdk4 (Mus musculus) | 6480464 | CTD | sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 mRNA]; sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of CCNA2 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of CCNE1 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of E2F1 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of PCNA protein] | PMID:27217333 PMID:28003426 | |
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