GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | LHB | decreases activity | EXP | | 6480464 | CTD | Estradiol results in decreased activity of LHB protein | PMID:31212720 | LHB | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of LHB protein | PMID:10843175 | LHB | decreases secretion | EXP | | 6480464 | CTD | Estradiol results in decreased secretion of LHB protein | PMID:3299987 | LHB | increases abundance | EXP | | 6480464 | CTD | LHB protein results in increased abundance of Estradiol | PMID:23433069 | LHB | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with TGFB1 protein] results in increased expression of LHB mRNA; [FSHB protein co-treated with LHB protein co-treated with CGB3 protein] results in increased abundance of Estradiol | PMID:30165855 PMID:8263139 | LHB | decreases expression | ISO | Lhb (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of LHB mRNA; Estradiol results in decreased expression of LHB protein | PMID:10709760 PMID:25269483 PMID:26789235 PMID:29092056 | LHB | decreases expression | ISO | Lhb (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased expression of LHB mRNA; Estradiol results in decreased expression of LHB protein | PMID:16522720 PMID:16614383 PMID:20144698 PMID:21187122 | LHB | decreases secretion | ISO | Lhb (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased secretion of LHB protein | PMID:16614383 PMID:909588 | LHB | increases abundance | ISO | Lhb (Rattus norvegicus) | 6480464 | CTD | CGB3 protein results in increased abundance of Estradiol | PMID:23312234 | LHB | increases expression | ISO | Lhb (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of LHB protein | PMID:29360751 | LHB | increases secretion | ISO | Lhb (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased secretion of LHB protein; LHB protein results in increased secretion of Estradiol | PMID:18162529 PMID:20951796 PMID:21303948 PMID:22247282 | LHB | multiple interactions | ISO | Lhb (Mus musculus) | 6480464 | CTD | ESR1 affects the reaction [Estradiol results in decreased expression of LHB protein] | PMID:10709760 | LHB | multiple interactions | ISO | Lhb (Rattus norvegicus) | 6480464 | CTD | [[Estradiol co-treated with Testosterone] results in decreased secretion of LHB protein] which results in decreased abundance of Testosterone; [Estradiol co-treated with Progesterone] results in decreased secretion of LHB protein; [Estradiol co-treated with Progesterone] results in increased expression of LHB protein; [Estradiol co-treated with Testosterone] results in decreased secretion of LHB protein; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [Testosterone co-treated with Estradiol] results in decreased secretion of LHB protein; bisphenol A inhibits the reaction [Estradiol results in increased secretion of LHB protein]; bisphenol A promotes the reaction [Estradiol results in increased secretion of LHB protein]; Estradiol affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]; Estradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHB mRNA]; nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]; p-271 peptide inhibits the reaction [bisphenol A promotes the reaction [Estradiol results in increased secretion of LHB protein]]; p-271 peptide inhibits the reaction [Estradiol results in increased secretion of LHB protein]; PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein] | PMID:16574160 PMID:17596564 PMID:17640482 PMID:19215433 PMID:20951796 PMID:2113863 PMID:21187122 PMID:21303948 PMID:909588 | | ||||||||||||||||||||||
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