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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDSimvastatin results in increased expression of TGFB1 mRNAPMID:19262002
Tgfb1multiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]PMID:19080365
Tgfb1decreases expressionISOTgfb1 (Rattus norvegicus)6480464CTDSimvastatin results in decreased expression of TGFB1 mRNA; Simvastatin results in decreased expression of TGFB1 proteinPMID:15855201 PMID:16320597 PMID:19659652
Tgfb1increases activityISOTgfb1 (Rattus norvegicus)6480464CTDSimvastatin results in increased activity of TGFB1 proteinPMID:21844074
Tgfb1increases expressionISOTgfb1 (Rattus norvegicus)6480464CTDSimvastatin results in increased expression of TGFB1 mRNAPMID:20024970 PMID:20687301
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of ACTA2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 protein]PMID:15298857 PMID:15677772
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