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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases activityISOTgfb1 (Rattus norvegicus)6480464CTDPhenobarbital results in decreased activity of TGFB1 proteinPMID:11238185
Tgfb1increases expressionISOTgfb1 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of TGFB1 mRNA; Phenobarbital results in increased expression of TGFB1 proteinPMID:30047161 PMID:8055622
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TGFB1 protein; myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TGFB1 protein]; Phenobarbital inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TGFB1 protein]; TGFB1 protein promotes the reaction [Phenobarbital results in increased abundance of Peroxides]PMID:10200566 PMID:28414157 PMID:9806150
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