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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDGenistein results in decreased expression of TGFB1 mRNAPMID:20816778
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTD[Taurine co-treated with epigallocatechin gallate co-treated with Genistein] inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [Galactosamine results in increased expression of TGFB1 mRNA]; Genistein inhibits the reaction [Galactosamine results in increased expression of TGFB1 protein]; Genistein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]PMID:12580099 PMID:21704028 PMID:23274713 PMID:25448286 PMID:27876602
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