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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69095
Species: Homo sapiens
RGD Object: Gene
Symbol: TGFB1
Name: transforming growth factor beta 1
Acc ID: CHEBI:8426
Term: probenecid
Definition: A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Chemical ID: MESH:D011339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGFB1multiple interactionsEXP 6480464CTDProbenecid inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein]PMID:23325087
TGFB1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTD[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]PMID:35114312
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