GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TGFB1 | affects response to substance | EXP | | 6480464 | CTD | TGFB1 protein affects the susceptibility to Hydrogen Peroxide | PMID:32980322 | TGFB1 | increases expression | EXP | | 6480464 | CTD | Hydrogen Peroxide results in increased expression of TGFB1 mRNA; Hydrogen Peroxide results in increased expression of TGFB1 protein | PMID:12573136 PMID:15147944 PMID:32980322 | TGFB1 | multiple interactions | EXP | | 6480464 | CTD | Clofibrate inhibits the reaction [Hydrogen Peroxide results in increased expression of TGFB1 mRNA]; Hydrogen Peroxide affects the reaction [tubeimoside II affects the reaction [TGFB1 protein affects the expression of CDH1 protein]]; Hydrogen Peroxide affects the reaction [tubeimoside II affects the reaction [TGFB1 protein affects the expression of VIM protein]]; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Hydrogen Peroxide inhibits the reaction [tubeimoside II inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased oxidation of EGFR protein]]; Hydrogen Peroxide promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; pirinixic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of TGFB1 mRNA]; TGFB1 protein affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]; TGFB1 protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALDH3A1 protein]; TGFB1 protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of LMNB1 protein]; TGFB1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]; TGFB1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] | PMID:12573136 PMID:24762191 PMID:32980322 PMID:33412154 | TGFB1 | decreases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Hydrogen Peroxide results in decreased expression of TGFB1 mRNA | PMID:11163763 | TGFB1 | increases expression | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of TGFB1 mRNA; Hydrogen Peroxide results in increased expression of TGFB1 protein | PMID:16284289 PMID:23159718 | TGFB1 | multiple interactions | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | Estradiol inhibits the reaction [Hydrogen Peroxide results in increased expression of TGFB1 mRNA]; Estradiol inhibits the reaction [Hydrogen Peroxide results in increased expression of TGFB1 protein]; Progesterone promotes the reaction [Hydrogen Peroxide results in increased expression of TGFB1 mRNA]; Progesterone promotes the reaction [Hydrogen Peroxide results in increased expression of TGFB1 protein] | PMID:16284289 | | ||||||||||||||||||||||
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